Ankylosing Spondylitis (AS)

While the precise cause of Ankylosing Spondylitis (AS) remains elusive, genetics, particularly the HLAB27 gene, is a pivotal factor. Recent studies underscore the influence of additional genes and bacterial infections in AS development. Predominantly impacting males under 35, AS can affect females as well. Stay informed about this complex interplay of genetic and environmental factors shaping AS.

Initial signs of Ankylosing Spondylitis (AS) often include gradual onset of persistent pain and stiffness in the lower back and buttocks, typically over weeks or months.

• The dull, diffuse pain intensifies in the mornings and nights but may ease with gentle exercise.
• Pain may extend to the ribs, neck, and other joints such as the shoulders, hips, ankles, knees.
• Heel pain
• Impact on the eyes, causing redness, pain, and blurred vision in a condition known as Uveitis.

Early recognition and tailored management are crucial for optimal outcomes.

Diagnosing Ankylosing Spondylitis (AS) relies on a combination of clinical history and pertinent investigations.

• Onset before 35 years and persistent pain for over 3 months.
• Reduced spinal mobility evident even in early stages.
• Sacroiliitis- A hallmark indication is sacroiliac joint (SI joint) involvement. While X-rays may reveal changes over a decade, MRI provides early detection within the first year, facilitating a prompt diagnosis.

HLAB27 is a normal gene found in 8% of the population; however, only 5% of individuals with this gene develop Ankylosing Spondylitis (AS). In suspected AS cases, particularly in the early stages, the HLAB27 test proves valuable for an accurate diagnosis, aiding healthcare professionals in confirming the presence of this genetic marker and facilitating timely intervention.

Timely diagnosis of Ankylosing Spondylitis (AS) in patients with persistent low back pain is crucial. Early identification is paramount for initiating prompt management, preventing potential deformities in the spine. Detecting AS in its initial stages allows for effective interventions, improving long-term outcomes and enhancing the quality of life for individuals affected by this condition.

Early diagnosis and precise management are pivotal for Ankylosing Spondylitis (AS) patients to maintain a normal lifestyle.

• Supervised exercise programs play a key role, reducing pain and preventing the development of the characteristic bending posture.
• NSAIDs like Indomethacin effectively decrease spine inflammation, benefiting up to 75% of patients.
• Sulfasalazine is a valuable option for non-responders.
• Anti-TNF agents like Infliximab show promise in managing resistant cases, significantly enhancing quality of life.

Stay abreast of these evolving treatment options for optimal patient care

A favorable prognosis exists for individuals with Ankylosing Spondylitis (AS) when diagnosed early and managed effectively. Early intervention and appropriate treatment significantly contribute to patients leading normal, fulfilling lives. Regular monitoring, adherence to treatment plans, and proactive measures empower those with AS to maintain optimal health and well-being, underscoring the importance of timely and comprehensive care.

Welcome to our cutting-edge clinic, operating every Tuesday, where state-of-the-art facilities go beyond consultations. Our holistic approach includes

• Disease awareness classes
• Lifestyle programs
• Physiotherapy sessions
• Patient education
• Multidisciplinary team
• Latest tools for assessing disease activity
• Actively engagement in clinical trials and research

Our goal is to maximize medical attention for Ankylosing Spondylitis (AS) patients, striving for disease remission and improved quality of life in a cost-effective manner. Your well-being is our priority.

BASDAI (Bath Ankylosing Spondylitis Disease Activity Index):

• Purpose: It is a self-reported questionnaire designed to assess disease activity in individuals with ankylosing spondylitis.
• Components: It includes questions related to fatigue, spinal pain, joint pain, localized tenderness, and morning stiffness.
• Scoring: Patients rate their symptoms on a scale from 0 to 10, and the overall BASDAI score is calculated, providing an objective measure of disease activity. (Images to be taken from website )

ASDAS (Ankylosing Spondylitis Disease Activity Score):

• Purpose: ASDAS is a composite index that combines both patient-reported outcomes and clinical assessments to evaluate disease activity in ankylosing spondylitis.
• Components: It incorporates information such as back pain, peripheral joint pain and swelling, acute-phase reactants (like CRP), and patient global assessment.
• Scoring: The calculated ASDAS score helps categorize disease activity into different levels, ranging from inactive disease to high disease activity. (Images to be taken from website )